Pakadali pano, neotame yavomerezedwa ndi mayiko opitilira 100 kuti igwiritsidwe ntchito pazinthu zopitilira 1000.
Ndizoyenera kugwiritsidwa ntchito muzakumwa zoziziritsa kukhosi, ma yoghurt, makeke, ufa wachakumwa, mkamwa wamkamwa mwazakudya zina.Itha kugwiritsidwa ntchito ngati chokometsera patebulo pazakumwa zotentha ngati khofi.Zimakwirira zowawa .
HuaSweet neotame imagwirizana ndi muyezo wadziko la China GB29944 ndipo imakwaniritsa zofunikira za FCCVIII, USP, JECFA ndi EP.HuaSweet yakhazikitsa maukonde ogulitsa m'maiko opitilira makumi asanu ndi atatu ku Southeast Asia, Europe, South America, North America ndi Africa.
Mu 2002, FDA idavomereza kuti izikhala zotsekemera komanso zokometsera ku United States muzakudya zambiri, kupatula nyama ndi nkhuku. [3]Mu 2010, idavomerezedwa kuti igwiritsidwe ntchito muzakudya mkati mwa EU ndi nambala E961. [5]Yavomerezedwanso ngati chowonjezera m'maiko ena ambiri kunja kwa US ndi EU.
Ku US ndi EU, kudya kovomerezeka kwa tsiku ndi tsiku (ADI) kwa neotame kwa anthu ndi 0.3 ndi 2 mg pa kg ya thupi (mg/kg bw), motsatana.NOAEL kwa anthu ndi 200 mg/kg bw patsiku mkati mwa EU.
Kuyerekeza kudya kwa tsiku ndi tsiku kuchokera kuzakudya kumakhala pansi pamilingo ya ADI.Neotame yolowetsedwa imatha kupanga phenylalanine, koma mukamagwiritsa ntchito neotame, izi sizofunikira kwa omwe ali ndi phenylketonuria.Komanso ilibe zotsatira zoyipa mu mtundu 2 shuga.Sichimaganiziridwa kuti ndi carcinogenic kapena mutagenic.
Center for Science in the Public Interest imayika neotame ngati yotetezeka.